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Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
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Cerebrovascular Expansion Drug Vinpocetine with Stronger Effects 42971-09-5

Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
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Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
City: Zhuzhou
Province/State: Hunan
Country/Region: China
Tel: 86-181-8893-8037
Contact Person:
Miss vivian

Cerebrovascular Expansion Drug Vinpocetine with Stronger Effects 42971-09-5

Brand Name : purity
Model Number : 42971-09-5
Certification : GMP, ISO 9001, USP, BP
Place of Origin : CHINA
MOQ : 1G
Price : negotiable
Payment Terms : T/T, Western Union, MoneyGram,btc
Supply Ability : 1000kg/month
Packaging Details : foil bag or stealth
Model NO. : 42971-09-5
Purity : >99%
HS Code : 3001200010
Specification : USP/BP/EP
Grade : Pharmaceutical Grade
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Cerebrovascular Expansion Drug Vinpocetine with Stronger Effects 42971-09-5

Vinpocetine
Synonyms:3A,16A-Apovincaminic Acid Ethyl Ester;(3a,16a)-Eburnamenine-14-Carboxylic Acid Ethyl Ester;Cavinton;Ethyl Apovincamin-22-Oate;Eburnamenine;Eburnamenine-14-Carboxylic Acid Ethyl Ester
CAS: 42971-09-5
MF:C22H26N2O2
MW:350.45
EINECS:256-028-0
Chemical Properties:White crystal powder, odourless and tasteless. Soluble in chloroform or 96% ethanol, insoluble in water. The melting point is 147-147 oC (decomposition). [α]D20+114°(C=1,pyridine). UV maximum absorption (96% ethanol): 229,275,315 nm (ε28200120, 00710). Acute toxicity LD50 in mice and rats (mg/kg): 534503 oral; 240133.8 intraperitoneal injection; 58.7, 42.6 intravenous injection.
Usage:Cerebrovascular drug. A alkaloid extracted from apocynaceae plant, Vincamine derivatives. Selectively inhibit vascular smooth muscle calcium dependency phosphodiesterase, and increase the content of cGMP, expanse cerebral vascular, which in turn increase cerebral blood flow, improve cerebral circulation, but has little effects on the cardiovascular and blood pressure. Effectively, good tolerance, less adverse reaction. Used for dizziness, headache, memory disorders, movement disorder, aphasia, hypertensive encephalopathy, etc.. Can also be used in brain blood circulation obstacle caused by mental or neurological symptoms.
Packing:1kg/bag

Vinpocetine COA:

Product name
VINPOCETINE
Standard adopted
EP8.0

Items of analysis
SpecificationResults

Appearance

White or slightly yellow,crystalline powder

White crystalline powder

Solubility

Practically insoluble in water,soluble in methylene chloride,slightly soluble in anhydrous ethanol

Conforms

Identificantion(IR)

Meet the requirements

Contorms

Specific optical rotation

+127°~+134°

+132.7°

Ethyl vincaminae ( A )

Not more than 0.6%

Conforms

Apovincamine ( B )

Not more than 0.5%

Conforms

Methoxyvinpocetine ( C )

Not more than 0.3%

Not detected

Dihydrovinpocetine ( D )

Not more than 0.5%

Not detected

Other single impurity

Not more than 0.10%

Conforms

Total impurity

Not more than 1.0%

0.121%

Loss on drying

Not more than 0.5%

0.02%

Sulphated ash

Not more than 0.1%

0.03%

Assay (on the dried basis )

Not less than 98.5% and not more than 101.5%

100.0%
ConclusionQualified


Cerebral Vasodilator:

Vinpocetine is a cerebrovascular expansion drug and has a relatively stronger function than Vincamine. It can selectively increase cerebral blood flow, enhance and improve brain oxygen supply, promote metabolism, enhance the capacity of deformation for red blood cells, reduce blood viscosity, inhibit platelet aggregation, improve tissue metabolism. Vinpocetine is mainly used in the treatment of cerebral infarction sequela, cerebral hemorrhage sequelae, cerebral arteriosclerosis, etc. It can also used in the treatment of retinal vascular sclerosis and blood vessel spasm, the elderly deafness, and dizziness.
Vinpocetine is a half synthetic Vincamine derivative, and has the similar effect with Vincamine. It has a stronger expansion function for cerebrovascular selectively. Pharmacological effects are as follows:
Inhibit the activity of calcium dependency phosphodiesterase, increase the content of cAMP which can relax vascular smooth muscle, then relax vascular smooth muscle, and further increase cerebral blood flow.
Enhance the capacity of deformation of red blood cells, reduce blood viscosity, inhibit platelet aggregation, and thus improve blood flow and microcirculation.
Promote the brain tissue to absorb glucose, and promote the transformation of brain monoamine metabolism.
Inhibit the increase of brain lactic acid during cerebral ischemia, increase the ATP content, inhibit the generation of lipid peroxide in the brain, delay the occurring of spasm caused by cerebral ischemia, have the function of improving cerebral metabolism and protecting brain.

Vinpocetine Indications:

1. Neurology: all kinds of cerebrovascular disease and its sequelae.
2. Cardiology: coronary heart disease, hardening of the arteries and blood clotting abnormalities, etc.
3. Eye: all kinds of views of visual impairment caused by poor circulation, etc.
4. Otolaryngology: hearing loss, tinnitus, vestibular dysfunction, etc.
5. Neurosurgery: all kinds of craniocerebral surgery back function rehabilitation.

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