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Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
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Natural Gw-0742 Sarms Steroid Powder Crystalline Solid CAS 317318-84-6

Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
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Zhuzhou Yuancheng Hezhong Technology Development Co., Ltd.
City: Zhuzhou
Province/State: Hunan
Country/Region: China
Tel: 86-181-8893-8037
Contact Person:
Miss vivian

Natural Gw-0742 Sarms Steroid Powder Crystalline Solid CAS 317318-84-6

Brand Name : purity
Model Number : 317318-84-6
Certification : iso9001 gmp
Place of Origin : china
MOQ : 1g
Price : 1USD
Payment Terms : T/T, Western Union, MoneyGram
Supply Ability : 1000KG/MONTH
Packaging Details : foil bags or stealth packages
Appearance : White Crystalline Powder
Usage : It Is a Potent and Tissue-Selective Androgen Recep
EINECS : 259-415-2
Molecular Fomular : C21H17F4NO3S2
CAS : 317318-84-6
Standard : Enterprise Standard
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Top Quality GW 0742 Sarms Steroids Raw Powder Factory Supply CAS 317318-84-6


Description:

GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.

Applications:

GW0742 is a synthetic high affinity PPAR β/δ agonist, and its possible role in preventing the advance of inflammatory and apoptotic processes induced by bleomycin, that long-term leads to the appearance of pulmonary fibrosis. Our data showed that GW0742-treatment (0.3 mg/Kg, 10 percent DMSO, i.p.) has therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters detected by measurement of: 1) cytokine production; 2) leukocyte accumulation, indirectly measured as decrease of myeloperoxidase (MPO) activity; 3) IkBα degradation and NF-kB nuclear translocation; 4) ERK phosphorylation; 5) stress oxidative by NO formation due to iNOS expression; 6) nitrotyrosine and PAR localization; 7) the degree of apoptosis, evaluated by Bax and Bcl-2 balance, FAS ligand expression and TUNEL staining. Taken together, our results clearly show that GW0742 reduces the lung injury and inflammation due to the intratracheal BLEO--instillation in mice.


Reason for Choosing us:
1): Superior Quality and Competitive Price:
Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly.
2): Fast ,Safe and Well Disguised Delievery:
Well-trained and disciplined packing team and sufficient stock ensure the parcel can be delieveried to your hand fastly and safely by DHL, TNT, FedEx, HKEMS, UPS, etc.
3): Experienced in Exporting:
We have clients throughout the world. Products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries. Custome pass rate ≥99%
4): Flexible Payment terms:
T/T,Western Union,Money Gram,Bitcoin. There will always be a term that is convient to you.
5): Warmhearted Customer Service and After-sale Service:
The parcel's photos and tracking numbers will be sent to you once it is prepared. Any of your questions would be solved as soon as possible.


Quick Details:
Product NameGW0742
SynonymGW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID
CAS317318-84-6
EINECS259-415-2
Assay99%
Appearancecrystalline solid
Packing1kg net/foil bag, 5kg/drum.
StandardEnterprise Standard
StorageShading , Confined Preservation
UsageA small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.
Molecular FomularC21H17F4NO3S2
Molecular Weight471.49
Molecular Structure


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Jinyang base
Xinyang base
Crepis base

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